Cardiovascular disorder is one of the interdisciplinary fields in medicine. The proper diagnosis and following up the risk factors of Cardiovascular diseases is not only an important task in cardiology but also in so many other areas of major and minor clinical fields. Knowing the exact pathophysiology and the correlation of CVD with other comorbidities, beside reducing the prognosis time and severity of the disease itself, can prevent and reduce the mortality and morbidity rate of further illnesses as an underlying cause.
Hypertension and Atherosclerosis are common disorders with high correlation with other clinical fields in medicine as Ophthalmology, Dermatology and et. The device with the meticulous measurement of the essential Cardiovascular parameters such as AIx (for assessing the endothelial function especially in inflammatory responses to estimate relative causes and comorbidities), PWV (for evaluating the arterial stiffness as a crucial factor for atherosclerosis with relevancy to other diseases), SBPao and etc. has an indispensable role in precise diagnosis and prognosis of the illness and associated diseases.
Psoriasis is a chronic, immune-mediated inflammatory skin disease. psoriasis vulgaris the same as other Th1 inflammatory diseases (e.g., rheumatoid arthritis and systemic lupus erythematosus) is also related to enhancing the cardiovascular risk and accelerating atherosclerosis which commonly assessed by measuring arterial stiffness.
In this study several measurements, body height and weight, blood pressure, and body mass index (BMI) have been done. At the blood collection time by dermatologist according to the Psoriasis Area and Severity Index (PASI) the Psoriasis grading evaluated. Biochemical parameters after obtaining venous fasting blood sample such as Serum glucose, urea, creatinine, triglycerides, total cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels, and hsCRP (determined by ELISA) have been measured. with the non-invasive Artheriograph device the arterial stiffness values (systolic pressure, diastolic pressure, mean arterial blood pressure, pulse rate, pulse pressure, PWV, AIx, and CAP) have been monitored.
Comparing with the healthy group results show that patients with psoriasis without known cardiovascular risk factors, have a higher arterial stiffness, which is not related with disease length and it’s activity (PASI).
The hsCRP positively correlated with, and independently predicted, arterial stiffness.
The study confirms the relation of the systemic and chronic inflammation, and positive correlation between PWV and diastolic blood pressure, with increasing the arterial stiffness in Psoriasis sufferers.