The oestrogen production of ovaries falls earlier than menopause occurs. The diminished oestrogen level accelerates the atherosclerotic procedures causing decreased NO (nitrogen monoxide) synthesis, which increases the peripheral arterial tone of the small arteries and arterioles; endothelial/vascular dysfunction develops. As the increased arterial stiffness due to the above-mentioned vascular remodelling can be detected with Arteriograph, women who are candidates for an increased level of medical care, can be detected in due time.
Post-menopausal defines as the period of time when a woman has experienced 12 consecutive months without menstruation. Post-menopausal women have higher possibility for showing cardiovascular symptoms which means there is a connection between menopause with cardiovascular disease.
This study conducted a survey on 96 sexagenarian women without any noticeable cardiovascular diseases.
Their Aortic Pulse Wave Velocity (PWVao) measured non-invasivly with Arteriograph.
intima–media thickness measured by B-mode ultrasonography.
transthoracic echocardiographic study performed for assessing left ventricular diastolic dysfunction (LVDD).
Results showed 52% of women with mild LVDD which associated to significant increase in their PWVao. Therefore, aortic PWV could be seen as a significant predictor of LVDD.
Osteoprotegerin (OPG) is not only related to bone metabolism but also related to arterial stiffness. The increased cardiovascular risk associated with postmenopausal status could be explained by medial and intimal calcification associated with OPG levels. This study assesses the relationship between OPG plus other markers with aortic pulse wave velocity (PWVao) as a sign of arterial stiffness in postmenopausal women.
Aortic Pulse Wave Velocity was measured using Arteriograph. circulating OPG, osteopontin (OPN) and total matrix Gla protein (MGP) concentrations were determined using ELISA technique at the same day.
Results revealed that only circulating OPG is associated with PWVao not OPN and total MGP. Moreover, OPG may be a marker of the increased arterial stiffness and cardiovascular risk in postmenopausal women.